Journal article
M. Petrucci, Raumin S Neuville, M. F. Afzal, A. Velisar, C. Anidi, Ross W. Anderson, J. E. Parker, J. O'Day, K. B. Wilkins, H. Bronte-Stewart
2019
2019
Semantic Scholar
DOI
Cite
Cite
APA
Click to copy
Petrucci, M., Neuville, R. S., Afzal, M. F., Velisar, A., Anidi, C., Anderson, R. W., … Bronte-Stewart, H. (2019). Neural Closed Loop Deep Brain Stimulation for Freezing of Gait.
Chicago/Turabian
Click to copy
Petrucci, M., Raumin S Neuville, M. F. Afzal, A. Velisar, C. Anidi, Ross W. Anderson, J. E. Parker, J. O'Day, K. B. Wilkins, and H. Bronte-Stewart. “Neural Closed Loop Deep Brain Stimulation for Freezing of Gait” (2019).
MLA
Click to copy
Petrucci, M., et al. Neural Closed Loop Deep Brain Stimulation for Freezing of Gait. 2019.
BibTeX Click to copy
@article{m2019a,
title = {Neural Closed Loop Deep Brain Stimulation for Freezing of Gait},
year = {2019},
author = {Petrucci, M. and Neuville, Raumin S and Afzal, M. F. and Velisar, A. and Anidi, C. and Anderson, Ross W. and Parker, J. E. and O'Day, J. and Wilkins, K. B. and Bronte-Stewart, H.}
}
Abstract
Freezing of gait (FOG), a devastating symptom of Parkinson’s disease (PD), can be refractory to current treatments such as medication and open-loop deep brain stimulation (olDBS). Recent evidence suggests that closed-loop DBS (clDBS), using beta local field potential power from the subthalamic nucleus (STN) as the control variable, can improve tremor and bradykinesia; however, no study has investigated the use of clDBS for the treatment of FOG. In this study, we provide preliminary evidence that clDBS was superior to olDBS in reducing percent time freezing and in reducing freezing behavior (gait arrhythmicity) in a person with PD and FOG. These findings warrant further investigation into the use of clDBS to treat FOG while also minimizing the total energy delivered to maintain a therapeutic effect.